I am currently looking at the problems being solved in the intersection
between Glycomics and
Bioinformatics, often called
Glycoinformatics
in pursuit of a PhD. My work is based at the DKFZ, within
the Central spectroscopy department (Molecular modelling) headed by Willi von der Lieth. Funding for my PhD is
provided by the EUROCarbDB consortium, which has
been established for the development of a design for a distributed carbohydrate database.
I have previously worked on various proteomics
related bioinformatics projects at my previous employer, Proteome Systems,
as well as being leading both the development and bioinformatic research for the
GlycoSuite informatic tools.
My interests within glycoinformatics lie with mass spectrometry, automated
analysis and interpretation of spectra, establishment of data interchange
standards, as well as data visualisation and user interface design.
Joshi HJ, Harrison MJ, Schulz BL, Cooper CA, Packer NH, Karlsson NG
Development of a mass fingerprinting tool for automated interpretation of
oligosaccharide fragmentation data.
Proteomics,
4 (6),
1650-1664
2004
Pubmed
Karlsson NG, Wilson NL, Wirth HJ, Dawes P, Joshi HJ and Packer NH
Negative ion graphitised carbon nano-liquid chromatography/mass spectrometry
increases sensitivity for glycoprotein oligosaccharide analysis.
Rapid Commun Mass Spectrom
18,
2282-2292
2004
Pubmed
Cooper CA, Joshi HJ, Harrison MJ, Wilkins MR & Packer NH
Querying GlycoSuiteDB.
In: Handbook of Proteomic Methods (Conn, P. M., ed),
pp 233-239
New Jersey: Humana Press Inc
Cooper CA, Joshi HJ, Harrison MJ, Wilkins MR, Packer NH
GlycoSuiteDB: a curated relational database of glycoprotein glycan structures and their
biological sources. 2003 update.
Nucleic Acids Res.
Jan 31 (1),
511-3,
2003
Pubmed
Joshi HJ, Schulz BL, Karlsson NG
Method of identifying Glycan structures using Mass Spectrometer data
WIPO Number WO 2004/108742
Harrison MJ, Joshi HJ, Schulz BL
A method for determining the biological likelihood of theoretical compositions or
structures
WIPO Number WO 2005/031343
Joshi HJ, Harrison MJ, Liddell CA
2 Dimensional structure queries
WIPO number WO 2003/056453